The Best Weight Loss Clinics in Houston, TX (2026)
Among weight loss clinics in Houston, review histories vary a great deal: the clinics on this page hold 2,617 Google reviews between them, and one alone accounts for 1,368. Ratings sit close together, from 4.7 to 4.9 stars, so the size of each history and the hours each clinic keeps do most of the sorting.
Short answer
Clinic 45 comes first at 4.8 stars from 1,368 Google reviews, the largest review history here. Z Med Clinic and Med Spa has the top rating, 4.9 stars from 590 reviews, but also runs med spa and IV services. Houston Weight Loss Center - Heights (4.7 stars from 287 reviews) stands out for reviewers who praise clear explanations from its team.
How Houston's Weight Loss Clinics Compare
| # | Practice | Rating | Reviews | Best for |
|---|---|---|---|---|
| #1 | Clinic 45 | 4.8 | 1,368 | Most reviewed, Saturday hours |
| #2 | Z Med Clinic and Med Spa | 4.9 | 590 | Highest rating, Saturday hours |
| #3 | Houston Weight Loss Center - Heights | 4.7 | 287 | Clear explanations from staff |
| #4 | Champion Health and Wellness Clinics | 4.7 | 210 | Communication and follow-up |
| #5 | River Oaks Beauty and Weight Loss Center | 4.8 | 162 | Weight loss and med spa care |
Ratings and review counts from Google, checked Oct 2026.
The Clinics, One by One
- Address 8221 Gulf Fwy #400, Houston, TX 77017
- Hours Mon to Fri: 8:00 AM to 5:00 PM · Sat: 8:30 AM to 2:00 PM
As listed on Google, checked Oct 2026
Clinic 45 describes itself as an independent weight loss and aesthetic center and says it is owned and supervised by Joseph E. Sleiman M.D. Its website says it has 20 years of experience and 6 locations across Texas. The site lists weight loss injections, supplements, aesthetic services, internal medicine and IV therapy. This listing is on Gulf Freeway.
What people praise
- Friendly, professional staff
- A clinic reviewers call clean and welcoming
- A provider described as patient and courteous
- The largest review history on this page
Worth knowing
- Some of the reviews we read are about laser hair removal and IV therapy, not weight loss
Reputation scorecard
Volume ranked among 10 Houston listings
Our take: A sensible first call if you want a long review history and a Saturday morning slot. It sits first because 1,368 reviews at 4.8 stars outweighs a slightly higher rating from fewer people.
- Address 4101 Greenbriar Dr #238, Houston, TX 77098
- Hours Mon: 9:00 AM to 6:00 PM · Tue to Wed: 9:00 AM to 3:00 PM · Thu to Fri: 9:00 AM to 6:00 PM · Sat: 8:00 AM to 2:00 PM
As listed on Google, checked Oct 2026
Z Med Clinic and Med Spa says its wellness plans may include hormone support, weight management programs, IV hydration and nutritional guidance, and that licensed providers build each plan from your health history. Its website also lists med spa services for the skin. Google files it as a weight loss service, a family practice physician and a medical spa.
What people praise
- Staff described as friendly and professional
- Questions answered patiently, so people feel informed
- A clean, well organised clinic
- A nurse practitioner reviewers call understanding
Worth knowing
- Several reviews are about IV drips and skin treatments rather than weight loss
- Closes at 3:00 PM on Tuesday and Wednesday
Reputation scorecard
Volume ranked among 10 Houston listings
Our take: Suits someone who may want weight loss care alongside other services under one roof. Its 4.9 is the best rating here, but 590 reviews is fewer than the leader's 1,368, so it sits second.
- Address 1941 W T C Jester Blvd #101, Houston, TX 77008
- Hours Mon to Thu: 9:00 AM to 6:00 PM · Fri: 8:00 AM to 2:00 PM
As listed on Google, checked Oct 2026
Houston Weight Loss Center - Heights says it offers physician-supervised medical weight loss in Houston since 1996. Its website lists prescription options, including semaglutide and tirzepatide, with one-on-one counseling, and says each plan is directed by a physician or nurse practitioner. It also lists hormone therapy and peptide therapy.
What people praise
- A provider reviewers call supportive, straightforward and a good listener
- A nurse who takes time to explain things thoroughly
- Courteous, efficient front office
- Options presented along with lifestyle advice
Worth knowing
- Open weekdays only, with a short Friday ending at 2:00 PM
Reputation scorecard
Volume ranked among 10 Houston listings
Our take: Worth a call if good explanations matter more to you than weekend hours. Its 4.7 stars from 287 reviews puts it third, behind Clinic 45 and Z Med Clinic and Med Spa, which have larger review histories.
- Address 4295 San Felipe St #235, Houston, TX 77027
- Hours Mon to Thu: 9:00 AM to 5:00 PM · Fri: 9:00 AM to 3:00 PM
As listed on Google, checked Oct 2026
Champion Health and Wellness Clinics calls itself a full-service weight loss clinic serving the greater Houston area. The page text we could read was thin, so little else is known from its website. Google lists it as a weight loss service and a health spa, with an office on San Felipe Street.
What people praise
- Easy intake process
- Staff who answer questions and stay in touch while an order is on its way
- A provider who takes time to explain a patient's health
Worth knowing
- Its website gave us very little to read, so check what it offers by phone
Reputation scorecard
Volume ranked among 10 Houston listings
Our take: A reasonable pick for people who value responsive communication. Its 4.7 matches Houston Weight Loss Center - Heights, but 210 reviews against 287 puts it one place lower.
- Address 510 Waugh Dr, Houston, TX 77019
- Hours Mon: 9:00 AM to 6:15 PM · Tue: 10:00 AM to 6:15 PM · Wed: 9:00 AM to 6:15 PM · Thu: 10:00 AM to 6:15 PM · Fri: 7:00 AM to 1:30 PM
As listed on Google, checked Oct 2026
River Oaks Beauty and Weight Loss Center says on its website that its weight loss programs are medically supervised. The site also lists aesthetic, laser, wellness and body treatments, and skin care. Google files it as a weight loss service, a medical spa and a laser hair removal service, with an office on Waugh Drive.
What people praise
- Staff described as knowledgeable, kind and patient
- A team that takes time to explain things
- A clean, modern, welcoming office
- A doctor and team reviewers call attentive and organised
Worth knowing
- Some reviews are about wellness shots and cosmetic services rather than weight loss
- Open weekdays only, with Friday ending at 1:30 PM
Reputation scorecard
Volume ranked among 10 Houston listings
Our take: Suits someone who wants weight loss care and med spa services in one place and doesn't need weekend hours. Its 4.8 rests on 162 reviews, the smallest history here, so it sits fifth.
How We Rank
Google's numbers, unedited
Ratings and review counts are Google's, read in October 2026. We never change them.
Who makes the list
Each business is filed under a weight loss category by Google, has an address in Houston and is rated 4.0 or higher. A company appears once.
Rating weighed by volume
A big review history counts for more than a perfect score from a handful of people. We started from a pool of 10 Google listings.
What each card shows
Each scorecard shows the rating, the size of the review history, the share of four and five star ratings, and whether Google lists a website, phone and hours.
Check the license
Prescription weight loss medicines can only be prescribed by a licensed clinician. Before you book, ask who prescribes at the clinic, then look that person up on the Texas medical or nursing board's public license search.
Questions to Ask Before You Book
- Who will prescribe, and what are their qualifications?
- What will a first visit and each follow-up cost in total, including any supplements?
- What happens if I want to stop or pause?
- How are side effects handled, and who do I call?
- Will my own doctor be kept informed?
- Which days and hours can I book, and what happens if the clinic runs late?
More Reviews
Frequently Asked Questions
How did you choose these weight loss clinics?
Each one is filed by Google under a weight loss category, has a Houston address and is rated 4.0 stars or higher. They are ordered by rating weighed by how many people gave it.
How often is this page updated?
Ratings and review counts were last read in October 2026.
Which Houston clinic has the most Google reviews?
Clinic 45, with 1,368 reviews at 4.8 stars. Z Med Clinic and Med Spa has the highest rating, 4.9 stars, from 590 reviews.
Which clinics are open on Saturday?
Google lists Saturday hours for Clinic 45 (8:30 AM to 2:00 PM) and Z Med Clinic and Med Spa (8:00 AM to 2:00 PM). The others list weekday hours only. Call first, as hours change.
Which clinics also offer other services?
Clinic 45's website lists aesthetic services, internal medicine and IV therapy. Z Med Clinic and Med Spa's website lists med spa services and IV hydration. Houston Weight Loss Center - Heights lists hormone therapy and peptide therapy. River Oaks Beauty and Weight Loss Center's website lists aesthetic and laser treatments.
The Bottom Line
On the numbers, Clinic 45 is the steady default: the biggest review history and a Saturday slot. Z Med Clinic and Med Spa is the alternative if you want the top rating and other services in one place. Call your pick and ask the questions above before booking. This page is not medical advice, and your own doctor's view comes first.