Best Nootropic Stack

Cindy Wilson Thumb by Cindy Wilson
BS, Nutrition & Food Science

When it comes to living a healthy life, workout routines and a healthy diet are not all you need. A calm and healthy mental state also matters a lot.

With increasing workloads and career-oriented life approaches, it becomes necessary to keep track of your mental health. This is where the Nootropics Stack comes to help.

Nootropics are cognitive enhancers or smart drugs, which enhance the core functionality of the human brain. The functional compound of these drugs are majorly neuron-enhancers, which improves:

  • Memory,
  • Learning capacity,
  • Motivation,
  • Attention & Concentration.[1]

With the increased demand in the market, nootropic stack has become the center of research. But many people know nothing about what makes the best nootropic stack and how they should use them.

This post will be an extensive go-to guide for you about the best nootropic stack with the details of what they are, how you can use them, and what to consider while purchasing one for yourself. Moreover, we will mention the facts from recent researches on the effects and benefits of nootropic stacks.

What is Nootropic & Nootropic Stack?

Nootropic and Nootropic stacks are two interchangeable terms that we will use throughout the article. Basically, nootropics are single compounds with cognitive functionality, i.e., Ginkgo biloba, Panax Ginseng, and Rhodiola Rosea. If we make a compound of these nootropics, it will be called a nootropic stack.

A nootropic stack is supposed to have a higher efficiency than a simple nootropic because of its combination. When consumed, these drugs induce an increase in the neurotransmitter and improve Synaptic Transmissionthe process of communication between two neurons.[2]

Not all nootropic stacks are formulated for the same target. Indeed, all have somewhat similar effects and overall same benefits. But the functionality of each formulation makes it different from the other.

Depending on the chemistry of ingredients, a nootropic stack can

  • Facilitates learning and improves memory.
  • Increase blood circulation and supply of oxygen and energy to the brain. [3]
  • Reduce inflammation.[4]
  • Stimulates the release of Dopamine and changes the mood.
  • Fights with anxiety and depression.

What Makes a Great Brain Supplement?

There are many best nootropic stacks available out there claiming to help you boost your memory, productivity, enhance mental energy, and help you fight against stress, anxiety, and fatigue. But not all are the same. There are basic components and ingredients which make the best nootropic stack.

So, before discussing the details of the best nootropic stacks, let’s cover the best nootropic ingredients.

1- Citicoline – Alertness, Memory, Energy

Citicoline (CDP choline) is a cholinergic compound that stimulates the transmission of acetylcholine. Studies have shown that CDP choline has a potential effect in improving the functionality of the human brain in alertness & attentional tasks.[5]

But that’s not all, which makes it a novel component of a nootropic stack. Citicoline also performs and regulates a diverse range of functions in the human body & brain. Some are:

  • Regulation of normal bodily functions, i.e., Lipid metabolism & Liver function. [6]
  • Improve memory and learning ability. [7]
  • Increase metabolism & provide energy [8]
  • Enhance neuroprotection.

Depending on these facts, many neurohackers are in favor to use Citicoline as a sole nootropic ingredient.

Besides, some studies show that proper supplementation of dietary Citicoline can help treat dementia, Alzheimer’s and resists the aging of brain cells. Thus, it increases the importance of Citicoline as a nootropic ingredient. [8]

Almost every nootropic stack contains Citicoline or any other cholinergic, such as Alpha GPC, which also induces acetylcholine transmission and facilitates learning & memory. [9]

2- L-Tyrosine – Anti-depressant

L-Tyrosine is dopaminergic, which plays a vital role in how we feel.[5] It is a natural amino acid that is readily available in natural food.

Depending on the cognitive functionality of L Tyrosine, it is considered one of the most effective ingredients of the nootropic stack. Studies have shown that L-Tyrosine improves response inhibition, task switching, and enhances memory, especially in demanding situations. [10]

Thus, helping the person to deal with the situation effectively.

The primary function of L-Tyrosine is fighting against depression and anxiety. Depression is linked to disruption of neurotransmitters, and tyrosine is a precursor of many neurotransmitters influenced by depression.

So, taking tyrosine in hard times can eventually make you strong enough to deal with depression, changes your mood, and improve the core cognitive functionality. [11]

3- Bacopa Monnieri – Resistant to Oxidative Stress

Bacopa is a popular herb and which is used for its therapeutic properties in ancient eastern medicines. According to Ayurvedic research, Bacopa Monnieri is famous as “Adaptogen”, – which enhances endurance, resistance and protects against stressful situations.[15]

Studies have shown sound evidence that Bacopa can effectively reduce oxidative stress and resist age-related cognitive decline. [12] So, if you are going through tough times in your life, you don’t have to be worried about mental dysfunction.

Even if you take a small amount of it, you will perform remarkably in stressful situations.

4- Phosphatidylserine -Promotes Neuroprotection

Phosphatidylserine, also known as PS, is the major acidic phospholipid class, and it makes up 13–15% of the phospholipids in the human cerebral cortex.[13] The human brain is highly enriched with DHA, which is essential for proper functioning. And PS has a high DHA content.

Recent studies have shown that PS plays a crucial role in fighting against neurodegeneration. Neurodegeneration could be because of any reason, including oxidative stress, neuroinflammation, and depression. But the anti-oxidant and anti-inflammatory properties of PS help in resisting the process.[14]

However, the PS levels decrease with aging. But PS supplements are clinically proven in enhancing cognitive function.[16]

Depending on these facts, PS is considered one of the essential ingredients of the best nootropic stack and, each nootropic stack of our list contains PS in considerable quantity. Thus, making the perfect stack for better results.

5- Huperzine A – Best Memory Enhancer

Huperzine A is a natural Acetylcholinesterase Inhibitor that inhibits the degeneration of acetylcholine. Acetylcholine is a neurotransmitter that contributes to many functions throughout the body and is abundant in motor neurons.[17]

So, it protects acetylcholine against degeneration, maintains its level, and activates the cholinergic system. Ultimately, it works as neuroprotective.

Since ancient times, Huperzine was a famous Chinese medicine used for fighting against dementia and many other diseases.[18] However, recent studies have proved that oral supplementation of Huperzine enhances the memory of the human brain. [19]

Especially for college students and university students, who encounter a significant decrease in their learning abilities and memory strength, a nootropic stack with Huperzine would be very effective.

6- Nutrients & Vitamins – Promotes Brain Health

Last but not least, nutrients and vitamins are also a part of the best nootropic stack.

Many nootropic stacks contain cobalamin (Vit. B12) and pyridoxine (Vit. B12) in significant amounts. Both of these vitamins are clinically proven for enhancing cognitive functionality, and their deficiencies can lead to cognitive deficits.[20]

Thus, keeping them in the list of important ingredients of the best nootropic stack is a must.

What To Look For In a Nootropic Stack

Various nootropic stacks are claiming to be the best out there. But not all are the best for every case. Their targets are also somewhat change depending on the formulation.

If you are looking for a nootropic stack for the first time, you must be confused about what to look for. So, here is what you should consider while purchasing a nootropic stack.

  • Ingredients – A nootropic stack contains a variety of different ingredients. However, the best nootropic stack contains a significant number of ingredients from natural sources.
  • Long-term Benefits – In the long run, a nootropic stack helps improve cognition, fights dementia, and enhances learning capabilities.
  • Value – A nootropic stack will come with the best formulation in premium quality for its price and offer the best value.
  • Brand’s Image – Before purchasing a nootropic stack, make sure that the brand is trustworthy. Look for online reviews and feedbacks from the audience and check if anyone has encountered an issue.
  • Dosage – The dosage of a nootropic stack depends on its formulation. A nootropic that works perfectly fine on a single dosage is preferred to having over one pill.

Best Nootropic Stacks In 2021

Here is our list of the best nootropic stack for 2021.

We have done extensive research on each product on our list to ensure that they are free from synthetic and harmful ingredients.

Nevertheless, we recommend you consult with your physician to stay on the safe side.

  1. Mind Lab Pro
  2. Qualia Mind
  3. BrainPill
  4. NooCube
  5. Performance Lab Mind
  6. Alpha Brain
Best Nootropic Stacks

#1 Mind Lab Pro – Best Overall

How Does Mind Lab Pro Help?

  • Increase alertness, focus, and mental energy.
  • Fight against anxiety, depression, and help you feel good.
  • Improve Cognition and memory recall.
  • Increase productivity.
  • Promote neuroprotection.

Mind Lab Pro is the leading brain supplement that comes with 11 effective ingredients. This one nootropic stack targets SIX mental pathways to improve and enhance brain functioning.

Therefore, most neurohackers consider Mind Lab Pro as Universal Nootropic.

The stack formulation is entirely research-based and designed in a way to promote 100% brainpower. The unique thing is their patented citicoline – Cognizin, which is clinically proven to enhance mental performance, memory recall, and brain energy.

Moreover, the formulation contains the best dopaminergic, N-Acetyl L-Tyrosine, and L-Theanine, from natural sources. So, if you want to fight against anxiety or depression, this stack will help you a lot.

Additionally, Mind Lab Pro contains many Herbal Nootropic Supplements that act as the best anti-oxidants and helps in enhancing memory and learning abilities.

Especially Lion’s Mane mushroom is of significant benefits. Research has shown that Lion’s Mane mushroom triggers the Nerve Growth Factor in our brain, which helps in repairing neurons.

On top of all, Mind Lab Pro is FDA approved, and GMP certified – they follow standard operating and regulatory procedures.


  • Citicoline (as Cognizin)
  • Bacopa Monnieri (arial parts)
  • Rhodiola Rosea (root)
  • Maritime Pine Bark Extract (95% proanthocyanidins)
  • Organic Lion’s Mane Mushroom (Full spectrum)
  • Phosphatidylserine (from sunflower lecithin)
  • N-Acetyl L-Tyrosine
  • L- Theanine (as Suntheanine)
  • Vitamin B6, B12, and B9.

Why Use Mind Lab Pro?

Brain functionality decreases with increasing age. Sometimes, it can even lead to some minor memory problems leading to dementia. To sustain brain health, a nootropic stack formulated from natural ingredients can help a lot.

Mind Lab Pro is a research-based stack containing the 11 best nootropics to improve your brain functions. The formulation targets six different pathways, including neurogenesis, neuro-protection, cerebral blood flow, brain energy, enhance neurotransmitters and prevent cognitive decline.

Unlike other nootropic stacks, Mind Lab Pro is free from Psychostimulant, i.e., caffeine, and contains the best herbs to enhance neurotransmitter acetylcholine. Moreover, Mind Lab Pro contains B vitamins that improve your mood, focus, memory recall, and take part in various brain functions.[21]


  • Vegan Friendly
  • Free from caffeine, GMOs, and allergens.
  • Patent Ingredients.
  • 30 day money-back guarantee
  • Contains no Racetams


  • Not available at any brick and mortar store.

#2 Qualia Mind

How Does Qualia Mind Help?

  • Improve cognition and focus.
  • Enhance learning ability and memory recall.
  • Boost energy in brain cells.
  • Promotes neurogenesis and increases oxygen flow.
  • Improves mood and helps you feel calm.
  • Resist cognition decline and promote neuroprotection.

Qualia Mind is the only nootropic stack that is formulated by advanced nootropics ingredients. It is one of all kinds of nootropics which contains every essential brain supplement including anti-oxidants, amino acids, B vitamins, Alpha GPC, and effective metabolic enhancer to promote brain health and core cognitive functions.

Qualia Mind is designed for those who need a notable improvement in their brain’s functionality for the long term. All ingredients of this stack are proven from research.

Alpha GPC triggers the release of the neurotransmitter acetylcholine and improves memory and learning.[9] The herbal supplements, i.e., Artichoke Leaf Extract, Rhodiola Rosea Root Extract, and Ginkgo Biloba and other herbs, are clinically proven to decrease oxidative stress, improve blood flow in brain, improve learning, focus, and mental stability in stressful situations.

Moreover, it is the only stack in our list containing Acetyl-L-carnitine, a metabolic enhancer that is clinically proven to give energy and improve cognition.


  • Alpha GPC
  • Cognizin
  • L-Tyrosine
  • L Theanine
  • Artichoke Leaf Extract
  • Bacopa Monnieri
  • Rhodiola Rosea Root Extract
  • Organic Coffeeberry
  • Velvet Bean Seed Extract
  • Celastrus Paniculatus Seed Extract
  • Ginkgo Biloba
  • Coleus Forskohlii Root Extract
  • Acetyl-L-carnitine
  • DL-Phenylalanine
  • Uridine-5
  • Taurine
  • Phosphatidylserine
  • Theobromine
  • DHA
  • Pyrroloquinoline Quinone
  • Vit C
  • Vit D3
  • Vitamin B6, B12, B5, B3, B1
  • Huperzine A

Why Use Qualia Mind?

Same as any other brain supplement, Qualia Mind is designed to optimize the brain’s functionality. But, unlike other nootropics stack, Qualia Mind has incredibly 28 ingredients backed by scientific research.

It makes it a fantastic solution for anyone looking for a quick burst in their brain health. For example, if you are a college student, you can consider using Qualia Mind in your exam season.

Although, the stack benefits are remarkable and help increase overall cognition. But for long-term daily use, it is not an ideal stack.


  • Have all vital high-quality nootropics.
  • Gives remarkable results, quickly.
  • Available with and without psychostimulant, i.e., caffeine.


  • Have a high daily dosage, 7-capsules a day.
  • Costly price.

#3 BrainPill

How Does BrainPill Help?

  • Improving clarity
  • Fight against fatigue
  • Protects and improves memory
  • Increase focus.
  • Boost learning stamina.

BrainPill is another favorite brain enhancement complex that is proven to energize your brain. It is decently formulated by using researched-backed natural ingredients to optimize the human brain.

Like other nootropic supplements, it also contains essential nootropics, but it is the only pick on our list with vinpocetine. Vinpocetine is a metabolic enhancer that ensures the availability of energy to brain. It also performs various tasks, including neuroprotection, resistance to inflammation, and improve focus.

Moreover, it also contains other potent cognitive enhancers, including L Theanine, citicoline, and range of B vitamins, including vitamin B6.


  • Citicoline
  • Bacopa Monnieri
  • Ginkgo Biloba
  • Vinpocetine
  • Phosphatidylserine
  • DHA Complex
  • Huperzine A
  • Tyrosine
  • L Theanine
  • Vitamin B6, B12, B5, and B9

Why Use BrainPill?

BrainPill is specifically designed to help in stressful circumstances by providing peak mental performance. It contains all high-quality, potent nootropics that are clinically proven in enhancing cognition, improving focus, and resist anxiety.

So, if you are noticing a cognitive decline or finding it hard to recall your memory, Brain Pill will be the best choice. The primary purpose of BrainPill is to improve focus, memory, and clarity.


  • Formulated with patented ingredients.
  • Free from caffeine and allergens.
  • 100% natural.
  • 67-day money-back guarantee.
  • GMP certified.


  • You can purchase it only from the official website.

#4 NooCube

How Does NooCube Help?

  • Enhancing Cognition.
  • Improving focus and concentration.
  • Improve learning and short-term memory.

NooCube is another pick under the best nootropic stacks, which is optimized for improving cognition. It is formulated with SIX essential nootropics, including L-Theanine – the best dopaminergic, which defines how you feel.

All ingredients of NooCube are the same as other stacks. But it is the only stack in our list which contains Oat Straw and Cat’s Claw as herbal supplements. According to research, Cat’s Claw has a powerful effect on cognition, and when combined with other nootropics, it creates a synergy to improve its impact.[22]


  • Alpha GPC
  • L-Theanine & L-Tyrosine
  • Cat’s Claw
  • Bacopa Monnieri
  • Oat Straw
  • Huperzine A

Why Use NooCube?

Instead of using a long list of ingredients, NooCube is uniquely formulated with herbal supplements, which creates a synergy to give remarkable results. It is a perfect stack of potent amino acids, vitamins, and cognitive enhancers.

Moreover, it is the best option at its price with an exceptional value for money. Two dosages per day in the breakfast are suggested, and their effect lasts for 8 to 10 hours.


  • Formulated with patented ingredients.
  • Have no side effects.
  • Gives notable results within 60 minutes.
  • Affordable pricing.


  • Not as advanced as other best nootropics listed above.

#5 Performance Lab Mind

How Does Performance Lab Mind Help?

  • Clinically tested for boosting brain energy up to 13.6%
  • It contains all essential compounds needed to improve performance-driven brain functionality
  • Compact ingredient list

Performance Lab Mind is formulated with potent nootropics, which gives the best long-term results. Overall, it is formulated with only FOUR nootropics but perfectly optimized for increasing focus and improving cognition.

The nootropics used are very well known and scientifically proven for their cognitive effects. Researches have proved the cholinergic properties of citicoline, which is clinically proven to influence attentional tasks, alertness, and reward processing.[5]

Other nootropics:

  • L-Tyrosine is proven for its dopaminergic activity.
  • Phosphatidylserine is proven for its neuroprotective properties.
  • Maritime Pine Bark Extract is proven for its anti-oxidant and adaptogen properties.


  • Citicoline
  • L-Tyrosine
  • Maritime Pine Bark Extract
  • Phosphatidylserine


  • 100% natural prebiotic-infused NutriCaps®.
  • GMP-certified.
  • 1-2 capsules per day are enough.
  • Free from caffeine and other stimulants.
  • Free from soy and other allergens.
  • No GMO & non-irradiated.
  • Vegan friendly.


  • Not optimized for short-term benefits.

#6 Alpha Brain

How Does Alpha Brain Help?

  • Perfectly formulated stack for improving cognition, memory, and focus.
  • Helps in stressful conditions to cope up with anxiety and depression.
  • It contains the best nootropics, which give synergistic effects and improves the core functionality.
  • All ingredients of this stack are from natural sources, clinically proven, caffeine-free, and vegan friendly.

Here is our last pick under the best nootropic stacks – Alpha Brain.

Alpha Brain is the only pick on our list, containing the best combination of nootropics from herbal sources. In addition to Bacopa and Oat straw, it contains Pterostilbene, which is proven in combating mitochondrial dysfunction. It also resists cognitive decline associated with aging.[27]

Besides, it contains L-Tyrosine, which is clinically tested to help under stressful conditions and improve cognition.[28] Other key ingredients, such as vitamin B6, Alpha GPC, and Vinpocetine, along with Phosphatidylserine, also give synergistic effects and help improve cognition, memory, and focus.


  • Alpha GPC
  • L-Tyrosine
  • L Theanine
  • Bacopa Monnieri Extract
  • Huperzia Serrata Extract
  • Cat’s Claw Extract
  • Oat Straw Extract
  • Pterostilbene
  • Vinpocetine
  • Phosphatidylserine
  • L-Leucine
  • Vitamin B6


  • No caffeine.
  • Keto-friendly and gluten-free.


  • Not as strong as Mind Lab Pro.
  • No return policy or money-back guarantee.

Why Use Nootropic Supplements?

Best Nootropic Supplements

With the advancement of science and technology, people are more concerned about how their brain works and how they can optimize it as per their needs. Nootropic stacks are one of the best options to help people in optimizing their mental abilities and capacities.

There are various reasons behind using nootropic stacks. However, the most common one is to boost memory, cognitive ability, fight against anxiety and depression, etc.

In general, nootropic stacks are used for TWO main reasons.

1-Medical treatment

Which includes treatment of mental disorders, including…

  • ADHD – Attention Deficit Disorder.
  • CFS – Chronic fatigue syndrome
  • Neurodegenerative disorders, and
  • Sleep wakefulness disorders.

2- Performance enhancement

Where people use nootropic stacks for gaining an edge over the competition. Such as,

  • Improving learning ability.
  • Increase focus and improve spatial orientation.
  • Improve concentration at work.
  • Fight against anxiety and depression.
  • Resist fatigue, and
  • Increase productivity.

What are the Side Effects of Nootropics?

Misuse of everything can lead to severe consequences, so the nootropics.

Generally, nootropic stacks have no side effects, and they pass the screening method as well. However, if you misuse nootropic stacks or even any simple nootropic ingredient, there will be some side effects. Such as,

  • Gastric discomfort
  • Fatigue
  • Insomnia
  • Dizziness
  • Headache, and 
  • Diarrhea 

These are the possible side effects of nootropics.[23]

However, the best nootropic stacks are formulated in such concentrations, which leave no room for side effects. Moreover, nootropic stacks are clinically tested for all kinds of side effects. That’s why all listed above nootropic stacks have no side effects.

Our Verdict

There are many nootropic stacks available out there. Each claims to be the best in terms of effectiveness and pricing. However, the best nootropic stacks are the one which contains essential cognitive ingredients including B vitamins, amino acids, and minerals to improve productivity, performance, focus, and memory.

Moreover, nootropic stacks should contain natural ingredients in the right amount to boost energy and potency. It must be free from all types of allergens and have no side effects on the person.

According to these standards, Mind Lab Pro is the best nootropic stack available at its price. Although its pricing is comparatively high, it worth it. Moreover, it tested for short-term cognitive enhancement as well as long-term brain health.

But keep in mind that this isn’t any medical advice. We research the best nootropic stacks and pick the best ones that fit our standards. For regular use of nootropic stacks for the long-term duration, we suggest consulting with your doctor.


What Is The Most Effective Nootropic?

It is the most heated topic in scientific research, but it is not confirmed which nootropic is the most effective. However, the data reported in the literature and previous studies, along with some recent researches, have shown that Cholinergicswith the ability to enhance neurotransmitter acetylcholine, are most effective against attention and memory deficits.[24]

Is Noopept the best nootropic?

Noopept is the brand name of a synthetic nootropic molecule that lies under the category f dopaminergic. Depending on its nature, Noopept influences dopamine, which plays a significant role in how you feel. Recent researches have claimed that Noopept has a strong cognitive ability and plays a vital role in improving memory. [25]

Is L-Theanine, Caffeine, Noopept, and Choline a good nootropic stack?

Yes, L-Theanine, Caffeine, Noopept, and Choline are good nootropic stacks. Although unlike the natural nootropic stacks listed above, Noopept is the synthetic nootropic. But it is scientifically proven for cognitive properties.[25] Moreover, L-Theanine is a well-known anti-depressant, caffeine is a famous stimulant, and choline is the best cognitive enhancer.[5]

What is the best natural nootropic stack for sleep quality?

L-Theanine is the best nootropic stack for high-quality sleep. It is clinically proven that L-Theanine induces alpha waves in the brain, decreasing the tension levels by anxiolysis instead of sedation.[26]

What is the best nootropic stack for high-energy activity?

Various stacks are claiming to be effective for high-energy activity. However, from our picks, Mind Lab Pro and Performance Lab are the best. Both stacks contain Maritime Pine Bark Extract and Phosphatidylserine in good amounts that are proven for increasing the energy in neurons.

Is green tea and caffeine a good nootropic?

Green tea is a well-known beverage that is famous for improving mental clarity and focus. According to recent studies, it has significant benefits including changing mood and improving cognitive function. However, the functionality can be improved if combined with psychostimulants, i.e., caffeine.[29] So, in light of this recent research, green tea and caffeine can be considered good nootropics.


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About Author

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BS, Nutrition & Food Science
Cindy Wilson

Hello, I am Cindy, and this a website where I inspect everything related to nutrition and a healthy lifestyle. I have a BS in Nutrition and Food Science (Colorado State University) and have completed a dozen specialty courses related to nutrition, biochemistry, and food science. I am open to learning more, but foremost I would like to share all my knowledge with you.

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